Neurodegenerative Disorders: Mechanisms and Prospects for Therapy

Chichester, U.K.: John Wiley & Sons, 1991. Neurological disorders, particularly the neurodegenerative diseases involving the central nervous system, are characterized by dysfunction and death of specific populations of nerve cells. Cellular and molecular neurobiological strategies have begun to clarify the mechanisms of neuronal degeneration and have led to the design of new approaches to prevent cell degeneration, promote cell survival, and restore the functions of diseased nerve cells. This book provides new information concerning these processes. Background papers review exciting new developments concerning: the mechanisms of neuronal degeneration caused by genetic factors, excitotoxins, and calcium; the molecular pathology leading to abnormalities in Alzheimer’s disease and the spongiform encephalopathies or prion diseases; the biological substrates of cell differentiation, axon guidance, and target recognition during development, repair, and recovery; and the potential therapeutic efficacies of growth factors and grafted cells in re-establishing circuits essential for the restoration of function. 301 pgs. Illustrated. Slight rubbing to corners and spine edges.. First Edition. Hard Cover. Fine/ . 8vo - over 7¾" - 9¾" tall.