Ir al contenido

Integration of Metabolism, Energetics, and Signal Transduction: Unifying
Foto de archivo: la portada puede ser diferente

Integration of Metabolism, Energetics, and Signal Transduction: Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Tapa dura - 2004 - 1st Edición

de Robert K. Ockner


Información de la editorial

Complex and unexplained phenomena tend to foster unorthodox perspectives. This publication is an example, as is a prior publication that emphasized the concept that intermediary metabolism might play a significant and determining role in hepatocyte proliferation and 1 tumorigenesis. Formulation of this hypothesis was based on an attempt to clarify several poorly understood phenomena; including the observations: 1) that xenobiotic peroxisome proliferators such as the fibrate hypolipidemic agents induce hepatocyte proliferation and carcinogenesis in rodents; 2) that benign and malignant liver tumors complicate the human syndrome of glycogen storage disease type I (glucose-6-phosphatase deficiency); and 3) that in this same syndrome, administration of glucose exerts an anti-tumor effect. Fatty acid and glucose metabolism are tightly linked in a we- established and profoundly inportant interplay. This connection, together with the fact that peroxisome proliferator-induced hepatocyte proliferation and carcinogenesis reflects inhibition of mitochondrial carnitine palmitoyltransferase-I and fatty acid oxidation, suggested the possibility that regulation of fatty acid metabolism could prove to be a pivotal determinant in the control of cell growth. In 1993, the year in which the paper cited above was published, insight into the importance of growth factors and signal transduction pathways in cell cycle regulation was increasing rapidly, but metabolic and energetic aspects of cell proliferation had attracted relatively little attention. Despite this, the concept seemed inescapable that the two seemingly distinct and unrelated determinants -- signal transduction and metabolism -- were integrally linked.

Descripción de contraportada

INTEGRATION OF METABOLISM,

ENERGETICS, AND SIGNAL TRANSDUCTION

Unifying Foundations in Cell Growth and Death, Cancer,

Atherosclerosis, and Alzheimer Disease

ROBERT K. OCKNER

"Dr. Ockner has written a fascinating and original book which explores potential metabolic links to neurodegeneration. He takes a fresh look at metabolic pathways involving interaction between astrocyte and neuron that are important for brain health and may play a significant role in the pathogenesis of Alzheimer disease and other normal and pathological phenomena. Dr. Ockner has a distinguished research career in fatty acid metabolism and the fatty acid binding proteins and writes with clarity upon this under-explored aspect of the brain in health and disease. Not only is his book important for understanding links between systemic and cerebral metabolism in neurodegeneration, but is a must read for scientists with an interest in the connection between metabolic pathways and brain function."

-- Dr. Bruce Miller,

Professor of Neurology

Clinical director of the Memory and Aging Center

University of California, San Francisco

"I find this book to be a commendable and comprehensive undertaking as it encompasses an evaluation of a wide area of scientific research. Researchers working in lipid metabolism to those interested in mitochondrial energetics and in the mechanisms of signal transduction pathways in cancer and Alzheimer disease will benefit from this book."

--M.A.Q. Siddiqui,

Professor and Chairman of the Department of Anatomy and Cell Biology

SUNY Downstate, Brooklyn, NY

Robert K. Ockner, M.D. is Professor of Medicine at the University of California, San Francisco, and is former Director of the UCSF Liver Center and Division of Gastroenterology. He and colleagues initially identified and characterized the cytosolic fatty acid binding proteins. He is a graduate of the Harvard Medical School and completed clinical and research training at Boston City Hospital, National Institutes of Health, and Massachusetts General Hospital.

Cover art by Sadie McFarlane

Detalles

  • Título Integration of Metabolism, Energetics, and Signal Transduction: Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer
  • Autor Robert K. Ockner
  • Encuadernación Tapa dura
  • Número de edición 1st
  • Edición 1
  • Páginas 387
  • Volúmenes 1
  • Idioma ENG
  • Editorial Springer
  • Fecha de publicación 2004-04-15
  • Ilustrado
  • ISBN 9780306484711 / 0306484714
  • Peso 1.6 libras (0.73 kg)
  • Dimensiones 9.2 x 6.5 x 1.2 pulgadas (23.37 x 16.51 x 3.05 cm)
  • Library of Congress subjects Cellular signal transduction, Pathology, Cellular
  • Número de catálogo de la Librería del Congreso de EEUU 2004047325
  • Dewey Decimal Code 616.07

Acerca del autor

Robert K. Ockner, M.D., Professor of Medicine at the University of California, San Francisco, graduated from Pomona College and Harvard Medical School, and completed clinical and research training at Boston City Hospital, National Institutes of Health, and Massachusetts General Hospital. He is former Director of the UCSF Division of Gastroenterology and the UCSF Liver Center, and served as Editor of Gastroenterology, Co-Editor of Progress in Liver Diseases, and Associate Editor of the Journal of Lipid Research. He and colleagues initially identified and characterized the cytosolic fatty acid binding proteins.

Ir arriba

Más ejemplares

Integration of Metabolism, Energetics, and Signal Transduction
Foto de archivo: la portada puede ser diferente

Integration of Metabolism, Energetics, and Signal Transduction

de Robert K. Ockner

  • Usado
  • very good
  • Tapa dura
  • Firmado
  • First
Estado
Usado - Very Good
Edición
1st Edition
Encuadernación
Hardcover
ISBN 10 / ISBN 13
9780306484711 / 0306484714
Cantidad disponible
1
Librería
Santa Monica, California, United States
Puntuación del vendedor:
Este vendedor ha conseguido 5 de las cinco estrellas otorgadas por los compradores de Biblio.
Precio
EUR 70.89EUR 53.17
¡Ahorra EUR 17.72!
EUR 5.20 enviando a USA

Mostrar detalles

Descripción:
Springer, 2004. First edition. Hardcover without dust jacket as issued. 4to with 387 pages. Signed on front free end paper, "To Marv, With warmest regards. Bob." The Book and DJ are in very good condition with very slight shelf wear. Interior clean and tight. Red-Black spine/White text.. Signed. 1st Edition. Hardcover. Very Good/No DJ as Issued. 4to. Hardcover.
Precio
EUR 70.89EUR 53.17
¡Ahorra EUR 17.72 !
EUR 5.20 enviando a USA
Integration of Metabolism, Energetics, and Signal Transduction : Unifying Foundations in Cell...
Foto de archivo: la portada puede ser diferente

Integration of Metabolism, Energetics, and Signal Transduction : Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease

de Robert K. Ockner

  • Nuevo
  • Tapa dura
Estado
New
Encuadernación
Hardcover
ISBN 10 / ISBN 13
9780306484711 / 0306484714
Cantidad disponible
717
Librería
Uxbridge, Greater London, United Kingdom
Puntuación del vendedor:
Este vendedor ha conseguido 5 de las cinco estrellas otorgadas por los compradores de Biblio.
Precio
EUR 112.64
EUR 9.45 enviando a USA

Mostrar detalles

Descripción:
Hard Cover. New. New Book; Fast Shipping from UK; Not signed; Not First Edition; The Integration of Metabolism, Energetics, and Signal Transduction : Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease.
Precio
EUR 112.64
EUR 9.45 enviando a USA
Integration of Metabolism, Energetics, and Signal Transduction
Foto de archivo: la portada puede ser diferente

Integration of Metabolism, Energetics, and Signal Transduction

de Ockner, Robert K.

  • Usado
Estado
UsedVeryGood The cover shows normal wear and tear.
ISBN 10 / ISBN 13
9780306484711 / 0306484714
Cantidad disponible
1
Librería
South San Francisco, California, United States
Puntuación del vendedor:
Este vendedor ha conseguido 5 de las cinco estrellas otorgadas por los compradores de Biblio.
Precio
EUR 94.48
EUR 4.72 enviando a USA

Mostrar detalles

Descripción:
UsedVeryGood The cover shows normal wear and tear. .
Precio
EUR 94.48
EUR 4.72 enviando a USA
Integration of Metabolism, Energetics, and Signal Transduction
Foto de archivo: la portada puede ser diferente

Integration of Metabolism, Energetics, and Signal Transduction

de Ockner, Robert K

  • Nuevo
  • Tapa dura
Estado
New
Encuadernación
Hardcover
ISBN 10 / ISBN 13
9780306484711 / 0306484714
Cantidad disponible
5
Librería
campbelltown, Florida, United States
Puntuación del vendedor:
Este vendedor ha conseguido 2 de las cinco estrellas otorgadas por los compradores de Biblio.
Precio
EUR 158.79
EUR 14.18 enviando a USA

Mostrar detalles

Descripción:
Springer. hardcover. New. 98x15x147. Brand New Book in Publishers original Sealing
Precio
EUR 158.79
EUR 14.18 enviando a USA