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Drug-Induced Mitochondrial Dysfunction Tapa dura - 2008 - 1st Edición
de James A. Dykens (Editor); Yvonne Will (Editor)
Descripción de contraportada
Preclinical screening for drug-induced mitochondrial dysfunction can predict toxicity and revolutionize drug development
All too often, despite adherence to regulatory guidelines, a new drug reaches the market and its toxicity is not discovered until many patients have been exposed. In many cases, this unpredicted toxicity is due to the drug's adverse effects on mitochondrial function or replication. This reference presents technological developments that facilitate preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue early in the drug development process. With chapters contributed by leading specialists in their areas, Drug-Induced Mitochondrial Dysfunction:
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Explains basic concepts so that non-specialists can understand mitochondrial function
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Discusses mitochondrial etiology of organ toxicity, covering the liver, heart, and kidney, as well as the skeletal muscle, nervous system, and lipoatrophy
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Details methodologies and techniques used to assess mitochondria function so researchers can address drug-induced mitochondrial impairment in their own labs
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Includes new models that detect drug-induced mitochondrial impairment in short-duration studies typical of preclinical drug evaluations
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Features both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development
This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry, including bench scientists and managers, and for pharmacologists and toxicologists in both drug and environmental health sciences.
Detalles
- Título Drug-Induced Mitochondrial Dysfunction
- Autor James A. Dykens (Editor); Yvonne Will (Editor)
- Encuadernación Tapa dura
- Número de edición 1st
- Edición 1
- Páginas 652
- Volúmenes 1
- Idioma ENG
- Editorial Wiley-Interscience
- Fecha de publicación 2008-09
- Ilustrado Sí
- Features Bibliography, Illustrated, Index
- ISBN 9780470111314 / 0470111313
- Peso 2.25 libras (1.02 kg)
- Dimensiones 9.3 x 6.3 x 1.3 pulgadas (23.62 x 16.00 x 3.30 cm)
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Temas
- Aspects (Academic): Clinical (Medicine)
- Library of Congress subjects Mitochondrial pathology, Mitochondria - physiology
- Número de catálogo de la Librería del Congreso de EEUU 2008002720
- Dewey Decimal Code 615.1
Reseñas en medios
Citas
- Scitech Book News, 03/01/2009, Page 88
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