Hiv-1 Integrase: Mechanism and Inhibitor Design Tapa dura - 2011 - 1st Edición
de Nouri Neamati (Editor); Binghe Wang (Editor)
Descripción de contraportada
Provides the Foundation Needed to Design Effective HIV-1 Integrase Inhibitors
Around the world, scientists have been working for years with the goal of designing effective HIV-1 integrase inhibitors in the battle against AIDS. This book reviews all their latest research findings on both inhibitor design and the mechanisms of action of HIV-1 integrase. Chapters have been contributed by leading pioneers in the field from North America, Europe, and Asia. These contributions represent not only a thorough review of the current literature, but also the authors' firsthand experience in drug development and design. Coverage includes such topics as:
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Integrase mechanism, structure, and function
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HIV-1 integrase-DNA interaction
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Host factors affecting provirus stability and silencing
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Role of metals in HIV-1 integrase inhibitor design
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Historic perspectives, challenges, and future opportunities
As the first publication to comprehensively examine HIV-1 integrase, this book is essential reading for anyone involved in inhibitor drug discovery.
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Integrates chemical, biochemical, and biological approaches, enabling readers to take full advantage of a promising target enzyme for combating HIV and retroviruses
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Illustrates rational drug design for a complex drug target with plenty of step-by-step examples
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Addresses drug design issues from a variety of perspectives to help readers understand both the challenges and opportunities of developing a successful HIV-1 integrase inhibitor
This book fills an important gap in the review literature, offering a valuable introduction to the field for scientists who need to collaborate with researchers in several disciplines in order to design drugs that effectively target HIV-1 integrase.
Detalles
- Título Hiv-1 Integrase: Mechanism and Inhibitor Design
- Autor Nouri Neamati (Editor); Binghe Wang (Editor)
- Encuadernación Tapa dura
- Número de edición 1st
- Edición 1
- Páginas 528
- Volúmenes 1
- Idioma ENG
- Editorial Wiley
- Fecha de publicación 2011-09
- Ilustrado Sí
- Features Bibliography, Illustrated, Index
- ISBN 9780470184745 / 0470184744
- Peso 3.2 libras (1.45 kg)
- Dimensiones 11 x 8.3 x 1.3 pulgadas (27.94 x 21.08 x 3.30 cm)
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Temas
- Aspects (Academic): Medical/Medicine Aspects
- Library of Congress subjects Drug Design, Antiviral agents
- Número de catálogo de la Librería del Congreso de EEUU 2010043285
- Dewey Decimal Code 616.979
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