T Lymphocytes Subpopulations in Immunotoxicology Tapa dura - 1998 - 1st Edición
de Ian Kimber (Editor); Maryjane K. Selgrade (Editor)
Descripción de contraportada
T Lymphocyte Subpopulations in Immunotoxicology Edited by Ian Kimber ZENECA Pharmaceuticals, Central Toxicology Laboratory, Macclesfield, Cheshire, UK and Mary Jane K. Selgrade US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, NC, USA Immunotoxicology is a diverse discipline that embraces the investigation of the adverse health effects that may result from the interaction of xenobiotics with the immune system. T lymphocytes orchestrate adaptive immune responses and are of central importance in the consideration of immunotoxicity. These cells and/or the tissue responsible for their functional maturation (the thymus) have been implicated as the primary or secondary targets for chemical insult. Moreover, T lymphocytes play pivotal roles in the induction and elicitation of chemical and protein allergy and in the pathogenesis of autoimmune disease. Classically, T lymphocytes have been divided into two main populations: CD4 helper T cells and CD8 suppressor/cytotoxic T cells. It is now apparent that there exists within both populations considerable functional heterogeneity, characterized usually by variable cytokine secretion patterns. Two major subpopulations of T helper (Th) cells have been identified and designated Th1 and Th2, with similar, but less well characterized, sub-types of cytotoxic (Tc) cells having been described also. The discovery of functional subpopulations of Th (and Tc) cells has profoundly influenced our view of the immune response and, in particular, our appreciation of the way in which the immune system can tailor responses to meet challenges of different types. This has also translated into a much more detailed understanding of certain immunopathologic processes and the role of T lymphocytes in the development of allergic, autoimmune and inflammatory diseases. This book explores the role of T lymphocyte subpopulations in the development and expression of immunotoxic effects. Constituent chapters reveal that a consideration of the impact of chemicals on these diverse T cell populations and the polarization of T cell responses has already contributed greatly to our understanding of the mechanisms underlying immunotoxicity, including immune suppression and allergic and autoimmune responses.
Detalles
- Título T Lymphocytes Subpopulations in Immunotoxicology
- Autor Ian Kimber (Editor); Maryjane K. Selgrade (Editor)
- Encuadernación Tapa dura
- Número de edición 1st
- Edición 1
- Páginas 312
- Volúmenes 1
- Idioma ENG
- Editorial Wiley, Chichester
- Fecha de publicación 1998-08-17
- ISBN 9780471971948 / 0471971944
- Peso 1.23 libras (0.56 kg)
- Dimensiones 9.26 x 6.16 x 0.88 pulgadas (23.52 x 15.65 x 2.24 cm)
- Library of Congress subjects T-Lymphocytes - immunology, Immunotoxicology
- Número de catálogo de la Librería del Congreso de EEUU 97044163
- Dewey Decimal Code 616.079
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