Vaccine Adjuvants Tapa dura - 2005
de Charles J. Hackett (Editor); Donald A. Harn Jr (Editor)
Descripción de contraportada
Recent major advances in our understanding of basic immunology have led to the development of powerful new adjuvants-substances that can stimulate the innate immune system and significantly improve the effectiveness of antigen-based vaccines. In Vaccine Adjuvants: Immunological and Clinical Principles, highly respected clinical immunologists and vaccine researchers detail the major research areas in this new era of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses. Among the highlights are an explanation of innate immune signaling-including Toll-like receptors-in vaccination, and a preview of emerging technologies in adjuvant research, such as microparticles and novel lipid and carbohydrate adjuvants.
Authoritative and eminently practical, Vaccine Adjuvants: Immunological and Clinical Principles moves from the basic principles of the innate immune system, through the characteristics of specific adjuvants, to detailed methods for developing the safer and more effective adjuvants that will trigger these powerful immune responses, and finally to the combinations of immune responses needed for successful vaccination.
Detalles
- Título Vaccine Adjuvants
- Autor Charles J. Hackett (Editor); Donald A. Harn Jr (Editor)
- Encuadernación Tapa dura
- Edición U. S. EDITION
- Páginas 284
- Volúmenes 1
- Idioma ENG
- Editorial Humana, Totowa, NJ
- Fecha de publicación 2005-12-01
- Ilustrado Sí
- Features Bibliography, Illustrated, Index
- ISBN 9780896038929 / 0896038920
- Peso 1.31 libras (0.59 kg)
- Dimensiones 9.21 x 6.14 x 0.69 pulgadas (23.39 x 15.60 x 1.75 cm)
- Library of Congress subjects Vaccines, Immunological adjuvants
- Número de catálogo de la Librería del Congreso de EEUU 2005046100
- Dewey Decimal Code 615.372
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