Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists Tapa dura - 2013 - 2nd Edición
de Robert a. Copeland
Descripción de contraportada
Offers essential guidance for discovering and optimizing novel drug therapies
Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid.
This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time.
Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers:
- Reversible modes of inhibitor interactions with enzymes
- Assay considerations for compound library screening
- Lead optimization and structure-activity relationships for reversible inhibitors
- Slow binding and tight binding inhibitors
- Drug-target residence time
- Irreversible enzyme inactivators
The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development.
The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields-- from pharmacology to medicinal chemistry to biophysics to clinical medicine.
Detalles
- Título Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists
- Autor Robert a. Copeland
- Encuadernación Tapa dura
- Número de edición 2nd
- Edición 2
- Páginas 576
- Volúmenes 1
- Idioma ENG
- Editorial Wiley-Interscience, U.S.A.
- Fecha de publicación 2013-03-18
- ISBN 9781118488133 / 111848813X
- Peso 2.1 libras (0.95 kg)
- Dimensiones 9.3 x 6.1 x 1.3 pulgadas (23.62 x 15.49 x 3.30 cm)
-
Temas
- Aspects (Academic): Biotechnology Aspects
- Número de catálogo de la Librería del Congreso de EEUU 2012045179
- Dewey Decimal Code 615.19
Más ejemplares
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists
de Robert A. Copeland
- Nuevo
- Tapa dura
- Estado
- New
- Encuadernación
- Hardcover
- ISBN 10 / ISBN 13
- 9781118488133 / 111848813x
- Cantidad disponible
- 6
- Librería
-
Southport, Merseyside, United Kingdom
- Precio
-
EUR 145.58EUR 11.77 enviando a USA
Mostrar detalles
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists
de Copeland, Robert A
- Nuevo
- Tapa dura
- Estado
- New
- Encuadernación
- Hardcover
- ISBN 10 / ISBN 13
- 9781118488133 / 111848813X
- Cantidad disponible
- 5
- Librería
-
campbelltown, Florida, United States
- Precio
-
EUR 192.27EUR 14.14 enviando a USA