Membrane Transporters: Methods and Protocols Tapa dura - 2003
de Qing Yan (Editor)
Primera línea
Membrane transporters play crucial roles in fundamental cellular functioning and normal physiological processes of archaebacteria, prokaryotes, and eukaryotes (1).
Descripción de contraportada
Membrane transporters and channels play key roles in drug absorption and distribution, influence drug efficacy and toxicity, and are the target of about 30% of currently marketed drugs. In Membrane Transporters: Methods and Protocols, a panel of recognized basic and clinical investigators-many world-famous-describe their proven, cutting-edge methodologies for studying these important proteins. Treated in step-by-step detail, these techniques take advantage of all the latest developments in biomedical research, including pharmacogenomics, bioinformatics, and microarray technologies. The authors explain databases and tools for bioinformatics analysis, provide practical guidelines for microarray experiments and data analysis, and illustrate the use of small-angle X-ray scattering, nuclear magnetic resonance (NMR), and molecular modeling to study the structural biology of membrane transporters. Methods for exploring structure-function correlation, such as site-directed mutagenesis, immunocytochemistry, and confocal microscopy, are also described, along with several methods that may help in the development of novel therapeutics. Each technique contains hands-on instructions, many notes on avoiding the problems that one may encounter, and suggestions for variant procedures.
Comprehensive and highly practical, Membrane Transporters: Methods and Protocols offers investigators working in biopharmaceutical science, drug discovery, and drug delivery both an array of powerful tools for work on membrane transporters and an essential guide to the state-of-the-art in the membrane transporter field today.
Detalles
- Título Membrane Transporters: Methods and Protocols
- Autor Qing Yan (Editor)
- Encuadernación Tapa dura
- Edición 1st
- Páginas 372
- Volúmenes 1
- Idioma ENG
- Editorial Humana, USA
- Fecha de publicación 2003-05-02
- Ilustrado Sí
- Features Bibliography, Illustrated, Index, Table of Contents
- ISBN 9781588291042 / 1588291049
- Peso 1.53 libras (0.69 kg)
- Dimensiones 9.44 x 6.52 x 1.1 pulgadas (23.98 x 16.56 x 2.79 cm)
- Library of Congress subjects Ion channels, Membrane proteins
- Número de catálogo de la Librería del Congreso de EEUU 2002192246
- Dewey Decimal Code 571.64
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