Inicio G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity de Roland Seifert (Editor); Thomas Wieland (Editor); Raimund Mannhold (Editor) (ISBN: 9783527308194)

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G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity Tapa dura - 2006

Name: G-protein-coupled receptors as drug targets; analysis of activation and constitutive activity
Price: 56.00 USD
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Author: Seifert, Roland and Thomas Wieland, eds
ISBN: 9783527308194

de Roland Seifert (Editor); Thomas Wieland (Editor); Raimund Mannhold (Editor)

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Información de la editorial

With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail current models and concepts, to introduce medicinal chemists, physiologists, pharmacologists, and medical researchers into the advances in the understanding of GPCR activation and constitutive activity. In addition, the book provides an overview on methods of investigating constitutive GPCR activity. The text is well illustrated by selected experimental data and schemes._The chaptes are all cross-referenced with each other and cover general mechnisms, methodological approaches and cover selected important GPCR sysstems, the consequences for drug action, including, side effects, and rational drug design for GPCR targets. A highly recommended reference for researchers in academia and industry. authors addresses in detail current models and concepts, so as to introduce pharmaceutical chemists, physiologists and medical researchers to the advances in the understanding of GPCR activation and constitutive activity, and provides an overview of the methods of investigating GPCR activity. The text is backed by abundant case studies and methodological advice for analyzing GPCRs, covering selected pharmacologically relevant GPCR systems, the consequences for drug action, including unwanted side effects, and rational drug design for GPCR targets.
A highly practical reference for researchers in academia and industry.

Detalles

Título G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity
Autor Roland Seifert (Editor); Thomas Wieland (Editor); Raimund Mannhold (Editor)
Encuadernación Tapa dura
Edición Volume 24
Páginas 304
Volúmenes 1
Idioma ENG
Editorial Wiley-Vch
Fecha de publicación January 9, 2006
Ilustrado Sí
ISBN 9783527308194 / 3527308199
Peso 1.5 libras (0.68 kg)
Dimensiones 9.6 x 6.9 x 0.8 pulgadas (24.38 x 17.53 x 2.03 cm)
Library of Congress subjects G proteins, Drug targeting
Número de catálogo de la Librería del Congreso de EEUU 2006295093
Dewey Decimal Code 615.7

Acerca del autor

Roland Seifert was born in 1960 in Berlin, Germany. He was fellow of the Merit Scholar Foundation of Germany and earned his MD degree at the Free University of Berlin in 1986. From 1986-1995 he worked in the group of Professor Gunter Schultz in the Department of Pharmacology of the Free University of Berlin. From 1995-1998, he worked with Dr. Brian Kobilka at Stanford University, CA, USA. From 1998-2004 he was Associate Professor in the Department of Pharmacology and Toxicology of The University of Kansas, Lawrence, KS, USA before taking over the Chair of Pharmacology and Toxicology at The University of Regensburg, Germany. His research focuses on the molecular mechanisms of GPCR-activation, G-protein function and adenylyl cyclase regulation.

Thomas Wieland was born in 1960 in Karlsruhe, Germany. He studied Pharmacy at the University of Heidelberg where he obtained his PhD in Pharmacology in 1989. From 1990-1996 he worked in the group of Professor Karl H. Jakobs in the Department of Pharmacology of the Universities of Heidelberg and Essen, Germany. From 1996 -1997, he was a research fellow with Dr. Melvin I. Simon at the California Institute of Technology, Pasadena, CA, USA. From 1997 - 2002 he was Professor in the Department of Pharmacology and Toxicology of the University of Hamburg, Germany. Since July 2002 he is Professor of Pharmacology and Toxicology at the University of Heidelberg, Germany. His research focuses on the GPCR induced activation of heterotrimeric G-proteins and monomeric GTPases and the regulation of these processes by accessory proteins.

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