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Mechanistic Studies of Drug-Disease and Drug-Drug Interactions
de Xinsheng Gu
- Usado
- Estado
- like new
- ISBN 10
- 3639173147
- ISBN 13
- 9783639173147
- Librería
-
Narashino, Aichi, Japan
Formas de pago aceptadas
Sobre este artículo
Internal pages are in excellent conditions, without any seal, writing, stain or rip. Just like new. The edges show minor wears. We will wrap the product carefully, and ship it from Japan. All our products are briefly disinfected and sealed in a waterproof envelope.
Every minute, we are exposed to and involuntarily absorb xenobiotics which may produce beneficial outcomes or harmful effects on our bodies. Drug metabolism is initially a defensive mechanism driven by certain enzymes to facilitate excretion and in turn reduce the body burden of the absorbed xenobiotics. However, the capacity of this protective system is regulated by factors including disease states, absorbed xenobiotics and genetic factors. Cytochrome P450 3A4 (CYP3A4) is the most abundant phase I drug metabolism enzyme in human liver and its expression levels affect the capacity of drug metabolism. In this book, mechanisms have been investigated on regulation of CYP3A4 gene expression through modulating pregnane X receptor transcriptional activity under inflammation and by xenobiotics. This book also introduces basic knowledge of xenobiotics and their disposition, drug metabolizing systems, nuclear receptors as xenosensors, as well as inflammation and NF-¿B. The information provided is useful to professionals and students in the fields of pharmaceuticals, pharmacy, medicinal therapeutics, chemical risk assessment and related scientific research.
Every minute, we are exposed to and involuntarily absorb xenobiotics which may produce beneficial outcomes or harmful effects on our bodies. Drug metabolism is initially a defensive mechanism driven by certain enzymes to facilitate excretion and in turn reduce the body burden of the absorbed xenobiotics. However, the capacity of this protective system is regulated by factors including disease states, absorbed xenobiotics and genetic factors. Cytochrome P450 3A4 (CYP3A4) is the most abundant phase I drug metabolism enzyme in human liver and its expression levels affect the capacity of drug metabolism. In this book, mechanisms have been investigated on regulation of CYP3A4 gene expression through modulating pregnane X receptor transcriptional activity under inflammation and by xenobiotics. This book also introduces basic knowledge of xenobiotics and their disposition, drug metabolizing systems, nuclear receptors as xenosensors, as well as inflammation and NF-¿B. The information provided is useful to professionals and students in the fields of pharmaceuticals, pharmacy, medicinal therapeutics, chemical risk assessment and related scientific research.
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Detalles
- Librería
- Wunderkammer Japan
(JP)
- Inventario del vendedor #
- FH5-O1W-23R
- Título
- Mechanistic Studies of Drug-Disease and Drug-Drug Interactions
- Autor
- Xinsheng Gu
- Estado del libro
- Nuevo
- Cantidad disponible
- 1
- Encuadernación
- Tapa blanda
- ISBN 10
- 3639173147
- ISBN 13
- 9783639173147
- Editorial
- Vdm Verlag
- Fecha de publicación
- 2009-08
- Catálogos del vendedor
- English language books; Medical Genre;
Términos de venta
Wunderkammer Japan
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Sobre el vendedor
Wunderkammer Japan
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